In silico efficacy of [S]-8-gingerol (a derivative) with 6-gingerol against PT-domain of Polyketide synthase A (PksA)


Short Communication

Author Details : Maneesh Kumar*

Volume : 7, Issue : 1, Year : 2021

Article Page : 62-64

https://doi.org/10.18231/j.ijmmtd.2021.014



Suggest article by email

Abstract

The PT-domain of Polyketide synthase A (PksA) is crucial product template that controls the aldol cyclization and aromatization to create polyketide precursor. The precursor leads to biosynthesis of aflatoxin secondary metabolites. Being carcinogenic in nature of these secondary metabolic, efforts have been made to explore novel inhibitors targeting the PT-domain of PksA. Previously, [6]-gingerol reported as a prospective inhibitor for the inhibition for aflatoxin biosynthesis, but some of its derivatives such as (S)-
[8]-gingerol, 9-Hydroxy-[6]-gingerol, 9-gingerol, 5-O-methyl-[9]-gingerol, methyl-6-gingerol, and [5]-gingerol exhibited better binding affinity. Notably, Leu1508, Asn1554, and Asn1568, are the key amino acid residues that are involved in stabilizing ligand-protein interaction. The study explores the understanding to develop new approach to create novel drug against the PT-domain to restrict the aflatoxin biosynthesis at initiation. However, a detailed in vivo study is required to further evaluation at in vivo stage.


How to cite : Kumar M , In silico efficacy of [S]-8-gingerol (a derivative) with 6-gingerol against PT-domain of Polyketide synthase A (PksA). IP Int J Med Microbiol Trop Dis 2021;7(1):62-64


Copyright © 2021 by author(s) and IP Int J Med Microbiol Trop Dis. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License (creativecommons.org)



View Article

PDF File   Full Text Article


Downlaod

PDF File   XML File   ePub File


Digital Object Identifier (DOI)

Article DOI

https://doi.org/10.18231/j.ijmmtd.2021.014


Article Metrics






Article Access statistics

Viewed: 120

PDF Downloaded: 58